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- Title
Lanthanide Tris(β-diketonates) as Useful Probes for Chirality Determination of Biological Amino Alcohols in Vibrational Circular Dichroism: Ligand to Ligand Chirality Transfer in Lanthanide Coordination Sphere.
- Authors
Miyake, Hiroyuki; Terada, Keiko; Tsukube, Hiroshi
- Abstract
ABSTRACT A series of lanthanide tris(β-diketonates) functioned as useful chirality probes in the vibrational circular dichroism (VCD) characterization of biological amino alcohols. Various chiral amino alcohols induced intense VCD signals upon ternary with racemic lanthanide tris(β-diketonates). The VCD signals observed around 1500 cm−1 (β-diketonate IR absorption region) correlated well with the stereochemistry and enantiomeric purity of the targeted amino alcohol, while the corresponding monoalcohol, monoamine, and diol substrates induced very weak VCD signals. The high-coordination number and dynamic property of the lanthanide complex offer an effective chirality VCD probing of biological substrates. Chirality 26:293-299, 2014. © 2014 Wiley Periodicals, Inc.
- Subjects
VIBRATIONAL circular dichroism; RACEMIC mixtures; CHIRALITY; METALLOENZYMES; AMINO alcohols
- Publication
Chirality, 2014, Vol 26, Issue 6, p293
- ISSN
0899-0042
- Publication type
Article
- DOI
10.1002/chir.22319