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- Title
Feasibility of the single-bolus strategy for measuring the partition coefficient of Gd-DTPA in patients with myocardial infarction: Independence of image delay time and maturity of scar.
- Authors
Thornhill, Rebecca E.; Prato, Frank S.; Wisenberg, Gerald; White, James A.; Nowell, Judith; Sauer, Anya
- Abstract
The partition coefficient of Gd-DTPA (λ) is elevated in infarcted relative to normal myocardium. Although MRI following an infusion of Gd-DTPA allows for the quantification of λ, infarct imaging is more routinely performed using a bolus. In this study we sought to determine how image delay time and time postinfarction influence the estimation of λ by the bolus strategy. Both infusion and bolus imaging were performed twice in the same group of patients ( N = 9): once at 3-4 weeks and again 6 months after reperfusion therapy for myocardial infarction (MI). Bolus estimates of λ were compared with those calculated after 60 min infusion, and comparisons were repeated at 6 months. The λ of infarcted myocardium was significantly greater than that of normal tissue, irrespective of either the technique used or the time postinfarction ( P < 0.0001, for each). The concordance ( R c) between bolus and infusion estimates of λ was >0.83 for all image delays >4 min postinjection, and R c at 2 min (0.78 ± 0.04) was significantly less than R c determined for longer image delay times ( P = 0.009). R c did not change with time postinfarction ( P = 0.604). Thus, the bolus strategy can be used to provide estimates of λ that are stable from 1-6 months postinfarction and independent of image delay time. Magn Reson Med, 2006. © 2006 Wiley-Liss, Inc.
- Publication
Magnetic Resonance in Medicine, 2006, Vol 55, Issue 4, p780
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.20830