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- Title
Stimulation of Titanium Implant Osseointegration Through High-Frequency Vibration Loading is Enhanced when Applied at High Acceleration.
- Authors
Ogawa, Toru; Vandamme, Katleen; Zhang, Xiaolei; Naert, Ignace; Possemiers, Tine; Chaudhari, Amol; Sasaki, Keiichi; Duyck, Joke
- Abstract
Low-magnitude high-frequency loading, applied by means of whole body vibration (WBV), affects the bone. Deconstructing a WBV loading stimulus into its constituent elements and investigating the effects of frequency and acceleration individually on bone tissue kinetics around titanium implants were aimed for in this study. A titanium implant was inserted in the tibia of 120 rats. The rats were divided into 1 control group (no loading) and 5 test groups with low (L), medium (M) or high (H) frequency ranges and accelerations [12-30 Hz at 0.3× g ( F A); 70-90 Hz at 0.075× g ( F A); 70-90 Hz at 0.3× g ( F A); 130-150 Hz at 0.043× g ( F A); 130-150 Hz at 0.3× g ( F A)]. WBV was applied for 1 or 4 weeks. Implant osseointegration was evaluated by quantitative histology (bone-to-implant contact (BIC) and peri-implant bone formation (BV/TV)). A 2-way ANOVA (duration of experimental period; loading mode) with α = 0.05 was performed. BIC significantly increased over time and under load ( p < 0.0001). The highest BICs were found for loading regimes at high acceleration with medium or high frequency ( F A and F A), and significantly differing from F A and F A ( p < 0.02 and p < 0.005 respectively). BV/TV significantly decreased over time ( p < 0.0001). Loading led to a site-specific BV/TV increase ( p < 0.001). The highest BV/TV responses were found for F A and F A, significantly differing from F A ( p < 0.005). The findings reveal the potential of high-frequency vibration loading to accelerate and enhance implant osseointegration, in particular when applied at high acceleration. Such mechanical signals hold great, though untapped, potential to be used as non-pharmacologic treatment for improving implant osseointegration in compromised bone.
- Subjects
OSSEOINTEGRATION; METALS in medicine; ARTIFICIAL implants; CONTROL groups; ACCELERATION (Mechanics); TITANIUM
- Publication
Calcified Tissue International, 2014, Vol 95, Issue 5, p467
- ISSN
0171-967X
- Publication type
Article
- DOI
10.1007/s00223-014-9896-x