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- Title
Synthesis and Biological Properties of Enkephalin-like Peptides Containing Carboranylalanine in Place of Phenylalanine.
- Authors
Schwyzer, Robert; Do, Kim Quang; Eberle, Alex N.; Fauchére, Jean-Luc
- Abstract
The syntheses of [ D-Ala2, Car4, Leu5]-enkephalin, its amide, and of [ D-Ala2, Car4, Met5]-enkephalin amide are described in detail. The three compounds show pronounced morphine-like potencies in certain bio-assays, and were used to investigate the influence of electronic, steric and hydrophobic properties of the side-chains of amino acids no. 4 and 5 on opioid activity (see [13]).
- Publication
Helvetica Chimica Acta, 1981, Vol 64, Issue 7, p2078
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19810640712