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- Title
Neurodegeneration: An expansion in ALS genetics.
- Authors
Lagier-Tourenne, Clotilde; Cleveland, Don W.
- Abstract
In this article the authors reflect on the association of short expansions of glutamine amino-acid residue in the ataxin-2 cytoplasmic protein with neuromuscular disorder amyotrophic lateral sclerosis (ALS). The authors stress that the mislocalization of TDP-43, an RND/DNA-binding protein, to the cytoplasm of neurons and and glial cells has been found in a growing number number of neurological disorders. Also, they explain how the TDP-43-dependent toxicity can be enhanced by ataxin-2.
- Subjects
AMYOTROPHIC lateral sclerosis; CYTOPLASM; NEURODEGENERATION; NEUROGLIA; NEURONS; PROTEINS
- Publication
Nature, 2010, Vol 466, Issue 7310, p1052
- ISSN
0028-0836
- Publication type
Opinion
- DOI
10.1038/4661052a