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- Title
Clinical characteristics of responders to intravitreal bevacizumab in central serous chorioretinopathy patients.
- Authors
Kim, G A; Rim, T H; Lee, S C; Byeon, S H; Koh, H J; Kim, S S; Lee, C S
- Abstract
PurposeTo investigate factors associated with good response to intravitreal bevacizumab (IVB) in central serous chorioretinopathy (CSC) patients.MethodsWe retrospectively reviewed 42 eyes of CSC patients of symptom duration more than 3 months who received a single or multiple successive IVBs on an as-needed basis (0.05 ml, 1.25 mg). High responders (HRs) were defined as complete resolution of subretinal fluid (SRF) on spectral domain optical coherence tomography (SD-OCT). Moderate responders (MRs) were defined as SRF resolution of 50-99% of pretreatment volume and poor responders (PRs) as SRF resolution <50%. Clinical, SD-OCT, fluorescein, and indocyanine green angiography findings were analyzed to find factors associated with HR. Descriptive statistics for all demographic and clinical variables were calculated, and comparisons were made using Wilcoxon's matched-pairs signed-rank test, the Mann-Whitney U-test for means with continuous data, Pearson's χ2 test, and Fisher's exact test for categorical data.ResultsThe mean number of IVB was 1.9. At postoperative 1 month, there were 10 (24%) HRs, 18 (43%) MRs, and 14 (33%) PRs. At the last follow-up (the mean 8.6 months), there were 25 HRs (60%), 9 MRs (21%), and 8 PRs (19%). Thicker subfoveal choroid (P=0.036), smaller lesion diameter (P=0.019), and better baseline best-corrected visual acuity (P=0.002) predicted HRs at postoperative 1 month. HR at the last follow-up was associated with classic pattern fluorescein angiography finding.ConclusionsSuboptimal effects of IVB on persistent CSC suggest primary IVB on selective cases with better vision, smaller lesion, and thicker choroid at baseline.
- Subjects
BEVACIZUMAB; ANTINEOPLASTIC agents; CHORIORETINITIS; TREATMENT of eye diseases; RETINAL diseases; OPTICAL coherence tomography; PATIENTS
- Publication
Eye, 2015, Vol 29, Issue 6, p732
- ISSN
0950-222X
- Publication type
Article
- DOI
10.1038/eye.2015.58