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- Title
The research progress of epigenetics and metabolic memory in diabetic kidney disease.
- Authors
Han-Zhou Li; Zi-Ang Ma; Ming-Yue Cui; Huan-Tian Cui; Shu-Quan Lv
- Abstract
Diabetic kidney disease (DKD) is a clinical syndrome that is one of the major causes of end-stage renal disease (ESRD). The pathogenesis of DKD is complex and multifaceted, with most studies indicating its association with genetics, advanced glycosylation end-product deposition, polyol pathway and protein C activation, lipid metabolism abnormalities, microcirculatory dysfunction, oxidative stress, inflammatory factors, and the kallikrein-kinin system. Epigenetics is the science studying gene expression regulation without changes in the DNA sequence. In recent years, increasing evidence has shown that epigenetic mechanisms play a crucial role in the initiation and progression of DKD. For instance, epigenetic modifications such as DNA methylation, histone modifications, and non-coding RNAs can influence the expression of DKD-related genes, thereby regulating the development and progression of DKD. On the other hand, metabolic memory is an important concept in DKD research. Metabolic memory refers to the phenomenon where cells maintain a certain metabolic state even after the disappearance of metabolic stress factors. This state can influence cell function and fate. In DKD, metabolic stress factors such as hyperglycemia can lead to metabolic memory in renal cells, affecting their function and fate, ultimately leading to the development and progression of DKD. Therefore, to further explore the pathogenesis of DKD, research on epigenetics should be strengthened, aiming to provide new ideas and methods for the prevention and treatment of DKD.
- Subjects
EPIGENETICS; DIABETIC nephropathies; CHRONIC kidney failure; DNA methylation; NON-coding RNA
- Publication
Life Research Journal, 2024, Vol 7, Issue 2, p1
- ISSN
2624-0548
- Publication type
Article
- DOI
10.53388/LR20240010