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- Title
Theta/Alpha Band Suppression and Clinical Outcomes During Globus Pallidus Internus Deep Brain Stimulation in Huntington's Disease.
- Authors
Martinez‐Horta, Saul; Aracil‐Bolaños, Ignacio; Perez‐Perez, Jesús; Perez‐Carasol, Laura; Garcia‐Cornet, Julia; Campolongo, Antonia; Aibar‐Duran, Juan Angel; Rodriguez‐Rodriguez, Rodrigo; Pascual‐Sedano, Berta; Kulisevsky, Jaime
- Abstract
We show that in HD, active DBS modulates theta/alpha and beta band suppression in the GPi, and we provide evidence on a clear clinical improvement after intervention. (C) Wavelet transformation of 10-seconds data into time-frequency domain showing the equivalent suppression DBS-ON of the theta/alpha frequency band and decrease of the low beta band predominating along LFP recordings. Keywords: LFPs; Huntington's disease; deep brain stimulation; DBS; GPi EN LFPs Huntington's disease deep brain stimulation DBS GPi 518 520 3 03/23/23 20230301 NES 230301 Bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) has been used for the treatment of hyperkinetic symptoms in Huntington's disease (HD).[[1], [3]] However, unlike other movement disorders, there is limited knowledge about the profile of frequency bands that predominate in the GPi in HD and about the effect of DBS on these frequency bands and on related clinical outcomes.[4] In previous studies of HD, local field potentials (LFPs) of the GPi recorded during OFF stimulation (DBS-OFF) showed a dominant theta/alpha activity similar to that observed in other hyperkinetic disorders.[[5]] In the present study, taking advantage of the capabilities of the new Medtronic PERCEPT implantable pulse generator (Medtronic, Minneapolis, MN),[7] we obtained LFPs of the GPi during DBS-OFF and DBS-ON in a gene-mutation carrier (CAG = 43), 43-year-old woman with symptomatic HD, characterized by pharmacologically uncontrollable choreatic movements in both the upper and lower extremities, dystonia, constant right-arm complex motor stereotypes, and vocalizations (Unified Huntington's Disease Rating Scale [UHDRS] total motor score = 82).
- Subjects
DEEP brain stimulation; HUNTINGTON disease; MOVEMENT disorders; GLOBUS pallidus; TREATMENT effectiveness; INFORMED consent (Medical law)
- Publication
Movement Disorders Clinical Practice, 2023, Vol 10, Issue 3, p518
- ISSN
2330-1619
- Publication type
Article
- DOI
10.1002/mdc3.13644