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- Title
Foot‐Hand Synkinesis in Corticobasal Syndrome: Single Clinical Feature with Distinct Molecular Imaging Biomarkers.
- Authors
Parmera, Jacy Bezerra; Brucki, Sonia Maria Dozzi; Coutinho, Artur Martins; Nitrini, Ricardo
- Abstract
Keywords: Synkinesis; corticobasal syndrome; positron emission tomography; [18F]fluorodeoxyglucose; amyloid PET EN Synkinesis corticobasal syndrome positron emission tomography [18F]fluorodeoxyglucose amyloid PET 491 492 2 04/03/21 20210401 NES 210401 Synkinesis is a subset of motor overflow in which voluntary movements of one part of the body are accompanied by involuntary activation of other, non-mirroring muscles.1 This disorder has been observed in neurodegenerative diseases such as Parkinson's disease,2 Creutzfeldt-Jakob disease,3 and other parkinsonian disorders.2,4 Moreover, it is also observed in healthy older subjects.2 Their occurrence in patients with corticobasal syndrome (CBS) might be expected, but this phenomenon is still scarcely described in the literature. Both patients underwent a comprehensive investigation that included magnetic resonance imaging (MRI), fluorodeoxyglucose (FDG)-positron emission tomography (PET), and Pittsburgh compound-B (PIB)-PET. Here, we report 2 cases of patients with probable CBS5 presenting ipsilateral and contralateral foot-hand synkinesis and distinct amyloid imaging biomarkers results.
- Subjects
HAND-foot syndrome; MAGNETIC resonance imaging; MOTOR cortex; CEREBRAL amyloid angiopathy; FUNCTIONAL magnetic resonance imaging
- Publication
Movement Disorders Clinical Practice, 2021, Vol 8, Issue 3, p491
- ISSN
2330-1619
- Publication type
Article
- DOI
10.1002/mdc3.13169