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Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo.
- Published in:
- Angewandte Chemie, 2017, v. 129, n. 47, p. 15159, doi. 10.1002/ange.201708847
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- Publication type:
- Article
An open-source automated PEG precipitation assay to measure the relative solubility of proteins with low material requirement.
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- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-01126-4
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- Article
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes.
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- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-36234-4
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- Article
Protein condensation diseases: therapeutic opportunities.
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- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32940-7
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- Publication type:
- Article
Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease.
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- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33252-6
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- Publication type:
- Article
Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer's Disease.
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- Pharmaceuticals (14248247), 2021, v. 14, n. 12, p. 1330, doi. 10.3390/ph14121330
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- Publication type:
- Article
Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo.
- Published in:
- Angewandte Chemie International Edition, 2017, v. 56, n. 47, p. 14963, doi. 10.1002/anie.201708847
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- Article
Human microglia, microglial LRRK2, and tau pathogenesis: a complex relationship.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082811
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- Article
A brain‐seeded fibril amplification models the aggregation process of tau in Alzheimer's disease for drug discovery.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082750
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- Article
O2‐02‐02: TARGETING AMYLOID FORMATION USING RATIONALLY DESIGNED ANTIBODIES.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P611, doi. 10.1016/j.jalz.2018.06.2646
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- Publication type:
- Article
O2‐01‐04: CELL TYPE–SPECIFIC TAU HOMEOSTASIS SIGNATURES ASSOCIATED WITH SELECTIVE VULNERABILITY OF EXCITATORY NEURONS TO TAU PATHOLOGY.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P609, doi. 10.1016/j.jalz.2018.06.2642
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- Publication type:
- Article
Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 22, p. 8651, doi. 10.3390/ijms21228651
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- Article
Rationally Designed Antibodies as Research Tools to Study the Structure–Toxicity Relationship of Amyloid-β Oligomers.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 12, p. 4542, doi. 10.3390/ijms21124542
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- Article
A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells.
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- International Journal of Molecular Sciences, 2018, v. 19, n. 5, p. 1443, doi. 10.3390/ijms19051443
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- Article
Nucleated Polymerisation in the Presence of Pre-Formed Seed Filaments.
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- International Journal of Molecular Sciences, 2011, v. 12, n. 9, p. 5844, doi. 10.3390/ijms12095844
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- Publication type:
- Article
Archaeal MBF1 binds to 30S and 70S ribosomes via its helix-turn-helix domain.
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- Biochemical Journal, 2014, v. 462, n. 2, p. 373, doi. 10.1042/BJ20131474
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- Article
Publisher Correction: Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response.
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- 2021
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- Correction Notice
Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response.
- Published in:
- Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02218-7
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- Article
The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage.
- Published in:
- eLife, 2017, p. 1, doi. 10.7554/eLife.23872.001
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- Article
Emergence and evolution of an interaction between intrinsically disordered proteins.
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- eLife, 2017, p. 1, doi. 10.7554/eLife.16059.001
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- Article
Structure of a low-population intermediate state in the release of an enzyme product.
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- eLife, 2015, p. 1, doi. 10.7554/eLife.02777.001
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- Article
pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins.
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- Nucleic Acids Research, 2014, v. 42, n. D1, p. D326, doi. 10.1093/nar/gkt960
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- Publication type:
- Article
The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25966-w
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- Publication type:
- Article
The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation.
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- EMBO Journal, 2021, v. 40, n. 21, p. 1, doi. 10.15252/embj.2020107568
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- Article
Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution.
- Published in:
- Nature Structural & Molecular Biology, 2015, v. 22, n. 7, p. 555, doi. 10.1038/nsmb.3035
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- Article
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers.
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- Nature Structural & Molecular Biology, 2015, v. 22, n. 3, p. 207, doi. 10.1038/nsmb.2971
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- Publication type:
- Article
Structural characterization of a misfolded intermediate populated during the folding process of a PDZ domain.
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- Nature Structural & Molecular Biology, 2010, v. 17, n. 12, p. 1431, doi. 10.1038/nsmb.1956
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- Publication type:
- Article
The mechanism of folding of Im7 reveals competition between functional and kinetic evolutionary constraints.
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- Nature Structural & Molecular Biology, 2009, v. 16, n. 3, p. 318, doi. 10.1038/nsmb.1562
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- Article
Using Side-Chain Aromatic Proton Chemical Shifts for a Quantitative Analysis of Protein Structures.
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- Angewandte Chemie, 2011, v. 123, n. 41, p. 9794, doi. 10.1002/ange.201101641
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- Publication type:
- Article
The amyloid state and its association with protein misfolding diseases.
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- Nature Reviews Molecular Cell Biology, 2014, v. 15, n. 6, p. 384, doi. 10.1038/nrm3810
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- Article
The amyloid state and its association with protein misfolding diseases.
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- Nature Reviews Molecular Cell Biology, 2014, v. 15, n. 7, p. 496, doi. 10.1038/nrm3826
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- Publication type:
- Article
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation.
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- Scientific Reports, 2017, v. 7, n. 1, p. 1, doi. 10.1038/s41598-017-08324-z
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- Publication type:
- Article
β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.
- Published in:
- Scientific Reports, 2016, p. 36010, doi. 10.1038/srep36010
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- Publication type:
- Article
Metadynamic metainference: Enhanced sampling of the metainference ensemble using metadynamics.
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- Scientific Reports, 2016, p. 31232, doi. 10.1038/srep31232
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- Publication type:
- Article
Towards a structural biology of the hydrophobic effect in protein folding.
- Published in:
- Scientific Reports, 2016, p. 28285, doi. 10.1038/srep28285
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- Publication type:
- Article
Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity.
- Published in:
- Scientific Reports, 2016, p. 27125, doi. 10.1038/srep27125
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- Publication type:
- Article
Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability.
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- Scientific Reports, 2016, p. 25559, doi. 10.1038/srep25559
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- Publication type:
- Article
Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein.
- Published in:
- Scientific Reports, 2016, p. 21994, doi. 10.1038/srep21994
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- Publication type:
- Article
The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments.
- Published in:
- Scientific Reports, 2015, p. 15449, doi. 10.1038/srep15449
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- Publication type:
- Article
Modulation of the Interactions Between α-Synuclein and Lipid Membranes by Post-translational Modifications.
- Published in:
- Frontiers in Neurology, 2021, v. 12, p. 1, doi. 10.3389/fneur.2021.661117
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- Publication type:
- Article
Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies.
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- Journal of Molecular Cell Biology, 2021, v. 13, n. 4, p. 282, doi. 10.1093/jmcb/mjaa075
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- Publication type:
- Article
A Simple Lattice Model That Captures Protein Folding, Aggregation and Amyloid Formation.
- Published in:
- PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0085185
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- Publication type:
- Article
In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within <i>E. coli</i> Cells.
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- PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0072286
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- Publication type:
- Article
Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region.
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- PLoS ONE, 2008, v. 3, n. 10, p. 1, doi. 10.1371/journal.pone.0003394
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- Publication type:
- Article
Efficient identification of near-native conformations in ab initio protein structure prediction using structural profiles.
- Published in:
- Proteins, 2010, v. 78, n. 2, p. 249, doi. 10.1002/prot.22533
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- Article
Molecular dynamics simulations from putative transition states of α-spectrin SH3 domain.
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- Proteins, 2007, v. 69, n. 3, p. 536, doi. 10.1002/prot.21491
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- Article
Characterization of the residual structure in the unfolded state of the Δ131Δ fragment of staphylococcal nuclease.
- Published in:
- Proteins, 2006, v. 65, n. 1, p. 145, doi. 10.1002/prot.21077
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- Article
Effective interactions between chaotropic agents and proteins.
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- Proteins, 2005, v. 61, n. 3, p. 492, doi. 10.1002/prot.20626
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- Publication type:
- Article
Principal eigenvector of contact matrices and hydrophobicity profiles in proteins.
- Published in:
- Proteins, 2005, v. 58, n. 1, p. 22, doi. 10.1002/prot.20240
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- Publication type:
- Article
Comparison of the transition state ensembles for folding of Im7 and Im9 determined using all-atom molecular dynamics simulations with ϕ value restraints.
- Published in:
- Proteins, 2004, v. 54, n. 3, p. 513, doi. 10.1002/prot.10595
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- Publication type:
- Article