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- Title
Encapsulation protocol for fecal microbiota transplantation.
- Authors
Sipos, Dávid; Varga, Adorján; Kappéter, Ágnes; Halda-Kiss, Bernadett; Kása, Péter; Pál, Szilárd; Kocsis, Béla; Péterfi, Zoltán
- Abstract
Introduction: Clostridioides difficile infections (CDI) continue to pose a challenge for clinicians. Fecal microbiota transplantation (FMT) is an effective treatment option in CDI. Furthermore, recent and ongoing studies suggest potential benefits of FMT in other diseases as well. Methods: We would like to present a novel protocol for encapsulation of lyophilized fecal material. Our method provides with better compliance as well as improved flexibility, storage and safety. Results: FMT was conducted in 28 patients with an overall success rate of 82,14% using apsules containing lyophilized stool. 16 of patients were given capsules with lessened bacteria counts. The success rate in this group was 93,75%. Discussion: The results highlight the still unanswered questions about the mechanism of action and contribute to a wider use of FMT in the clinical praxis and in research.
- Subjects
FECAL microbiota transplantation; CLOSTRIDIOIDES difficile; CLOSTRIDIUM diseases; FECES; MEDICAL research
- Publication
Frontiers in Cellular & Infection Microbiology, 2024, p01
- ISSN
2235-2988
- Publication type
Article
- DOI
10.3389/fcimb.2024.1424376