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- Title
TRP64ARG polymorphism of the β3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle.
- Authors
Marti, A.; Corbalán, M. S.; Martínez-Gonzalez, M. A.; Martinez, J. A.
- Abstract
Aim: We performed a case–control study to assess the association between obesity risk and the Trp64Arg polymorphism of the β3 -adrenergic receptor gene. Methods: Obese subjects [n = 159; body mass index (BMI) > 30 kg/m2 ] and controls (n = 154; BMI < 25 kg/m2 ) were compared using multivariable logistic regression to control for potential confounders. Results: A higher obesity risk (adjusted OR: 2.98; 95% CI: 1.00–8.56; p = 0.05) was associated with the Trp64Arg polymorphism among sedentary, but not among more active people. Conclusions: Our results suggest that the TRP64ARG polymorphism of the ADRB3 seems to be a risk factor for obesity that is dependent on a sedentary lifestyle.
- Subjects
OBESITY; ISOHORMONES; BODY weight
- Publication
Diabetes, Obesity & Metabolism, 2002, Vol 4, Issue 6, p428
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1046/j.1463-1326.2002.00227.x