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- Title
Human T and B cell epitope mapping of Taenia solium paramyosin.
- Authors
Vázquez-Talavera, José; Solís, Carlos F.; Medina-Escutia, Edith; López, Zoila Morales; Proaño, Jefferson; Correa, Dolores; Laclette, Juan Pedro
- Abstract
Taenia solium paramyosin is an immunodominant antigen in human and porcine cysticercosis that has shown promise as a vaccine candidate against schistosomiasis and some filariasis. There are few studies to identify the immunologically relevant regions of paramyosin. In this work, we characterize the humoral and cellular response of neurocysticercotic patients against T. solium paramyosin. Western blots using different recombinant fragments of T. solium paramyosin, showed that the sera from neurocysticercotic patients were strongly reactive against the carboxyl end region, with poor recognition of the central and amino regions. In contrast, the cellular immune response of patients did not show preferential recognition of any region of paramyosin.
- Subjects
LYMPHOCYTES; TAENIA
- Publication
Parasite Immunology, 2001, Vol 23, Issue 11, p575
- ISSN
0141-9838
- Publication type
Article
- DOI
10.1046/j.1365-3024.2001.00416.x