We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Bis (Diamines) Cu and Zn Complexes of Flurbiprofen as Potential Cholinesterase Inhibitors: In Vitro Studies and Docking Simulations.
- Authors
Jamil, Muhammad; Sultana, Nargis; Ashraf, Rizwan; Bashir, Maryam; Rehman, Muhammad Fayyaz ur; Kanwal, Fariha; Ellahi, Humna; Lu, Changrui; Zhang, Wei Xing; Tariq, Muhammad Ilyas; Garcia-Deibe, Ana
- Abstract
Alzheimer's disease (AD) causes dementia and continuous damage to brain cells. Cholinesterase inhibitors can alleviate the condition by increasing communication between the nerve cells and reducing the risk of dementia. In an effort to treat Alzheimer's disease, we synthesized flurbiprofen-based diamines (1,2 diaminoethane and 1,3 diaminopropane) Zn(II), Cu(II) metal complexes and characterized them by single-crystal X-ray analysis, NMR, (FT)-IR, UV-Vis, magnetic susceptibility, elemental analysis and conductivities measurements. Synthesized diamine metal complexes appeared in ionic forms and have distorted octahedral geometry based on conductivity studies, magnetic susceptibility and electronic studies. Single crystal X-ray diffraction analysis confirmed (2b) Cu(H2O)2(L1)2(L2)2 complex formation. Moreover, we tested all synthesized metal complexes against the cholinesterase enzyme that showed higher inhibition potential. In general, copper metal complexes showed higher inhibitory activities than simple metal complexes with flurbiprofen. These synthesized metal complexes may derive more effective and safe inhibitors for cholinesterases.
- Subjects
PHTHALIC acid; CHOLINESTERASE inhibitors; DIAMINES; FLURBIPROFEN; ALZHEIMER'S disease; METAL complexes; MAGNETIC susceptibility
- Publication
Crystals (2073-4352), 2021, Vol 11, Issue 2, p208
- ISSN
2073-4352
- Publication type
Article
- DOI
10.3390/cryst11020208