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- Title
First-Line and Maintenance Therapy for Ovarian Cancer: Current Status and Future Directions.
- Authors
González-Martín, Antonio; Sánchez-Lorenzo, Luisa; Bratos, Raquel; Márquez, Raúl; Chiva, Luis
- Abstract
Paclitaxel and carboplatin combination chemotherapy has remained the standard of care in the frontline therapy of advanced epithelial ovarian carcinoma during the last decade. Maintenance chemotherapy or immunotherapy has not been proven to impact on overall survival and only one clinical trial that explored the administration of monthly paclitaxel for 1 year showed a benefit in terms of progression-free survival (PFS), but at the cost of maintained alopecia and increased peripheral neuropathy. This scenario may be changing with the incorporation of targeted therapy to the frontline therapy of ovarian cancer. In particular, anti-angiogenic therapy has been identified as the most promising targeted therapy, and the addition of bevacizumab to first-line chemotherapy followed by a maintenance period of bevacizumab in monotherapy has shown to prolong PFS. This was considered the proof of concept of the value of anti-angiogenic therapy in the frontline of ovarian cancer, and the results of two additional clinical trials with anti-angiogenic tyrosine-kinase inhibitors have shown results in the same direction.
- Subjects
DRUG analysis; PACLITAXEL; BEVACIZUMAB; CARBOPLATIN; CANCER chemotherapy; COMBINATION drug therapy; GYNECOLOGY; MEDICAL needs assessment; NEOVASCULARIZATION inhibitors; OPERATIVE surgery; OVARIAN tumors; SURVIVAL; TUMOR treatment; THERAPEUTICS
- Publication
Drugs, 2014, Vol 74, Issue 8, p879
- ISSN
0012-6667
- Publication type
Journal Article
- DOI
10.1007/s40265-014-0221-9