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- Title
Prognostic Factors of Mortality in Nonchronic Obstructive Pulmonary Disease Chronic Lung Disease: A Scoping Review.
- Authors
Ng, Sheryl Hui Xian; Chai, Gin Tsen; George, Pradeep Paul; Kaur, Palvinder; Yip, Wan Fen; Chiam, Zi Yan; Neo, Han Yee; Tan, Woan Shin; Hum, Allyn
- Abstract
Introduction: Patients with chronic lung disease (CLD) experience a heavy symptom burden at the end of life, but their uptake of palliative care is notably low. Having an understanding of a patient's prognosis would facilitate shared decision making on treatment options and care planning between patients, families, and their clinicians, and complement clinicians' assessments of patients' unmet palliative needs. While literature on prognostication in patients with chronic obstructive pulmonary disease (COPD) has been established and summarized, information for other CLDs remains less consolidated. Summarizing the mortality risk factors for non-COPD CLDs would be a novel contribution to literature. Hence, we aimed to identify and summarize the prognostic factors associated with non-COPD CLDs from the literature. Methods: We conducted a scoping review following published guidelines. We searched MEDLINE, Embase, PubMed, CINAHL, Cochrane Library, and Web of Science for studies published between 2000 and 2020 that described non-COPD CLD populations with an all-cause mortality risk period of up to three years. Only primary studies which reported associations with mortality adjusted through multivariable analysis were included. Results: Fifty-five studies were reviewed, with 53 based on interstitial lung disease (ILD) or connective tissue disease-associated ILD populations and two in bronchiectasis populations. Prognostic factors were classified into 10 domains, with pulmonary function and disease being the largest. Older age, lower forced vital capacity, and lower carbon monoxide diffusing capacity were most commonly investigated and associated with statistically significant increases in mortality risks. Conclusions: This comprehensive overview of prognostic factors for patients with non-COPD CLDs would facilitate the identification and prioritization of candidate factors to predict short-term mortality, supporting tool development for decision making and to identify high-risk patients for palliative needs assessments. Literature focused on patients with ILDs, and more studies should be conducted on other CLDs to bridge the knowledge gap.
- Subjects
ONLINE information services; CINAHL database; MEDICAL databases; CAUSES of death; MEDICAL information storage &; retrieval systems; CARBON monoxide; LUNG diseases; SYSTEMATIC reviews; MORTALITY; MULTIVARIATE analysis; INTERSTITIAL lung diseases; RISK assessment; VITAL capacity (Respiration); OBSTRUCTIVE lung diseases; DECISION making; RESEARCH funding; LITERATURE reviews; MEDLINE; BRONCHIECTASIS; NEEDS assessment; PALLIATIVE treatment; DISEASE risk factors
- Publication
Journal of Palliative Medicine, 2024, Vol 27, Issue 3, p411
- ISSN
1096-6218
- Publication type
Article
- DOI
10.1089/jpm.2023.0263