We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Role of Soluble Fas/Fas Ligand Pathway and Osteoprotegerin in Diabetic Foot Ulceration.
- Authors
GÜLDİKEN, Sibel; TASKIRAN, Bengür; DEMİR, Ahmet Muzaffer; TUĞRUL, Ayşe Armağan; UĞUR ALTUN, Betül
- Abstract
Aim: Apoptosis contributes to atherosclerosis. Fas/Fas ligand promotes apoptosis while osteoprotegerin does the reverse. We aimed to investigate the role of these apoptosis markers in the pathogenesis of diabetic foot. Material and Methods: Thirty-eight type 2 diabetic patients with diabetic foot, 25 type 2 diabetic patients without diabetic foot and 25 control subjects were enrolled in the study. Diabetic foot lesions were graded according to Wagner classification. ELISA method was used to measure soluble Fas, soluble Fas ligand and osteoprotegerin levels in serum samples. Results: Osteoprotegerin, soluble Fas and soluble Fas ligand levels were significantly higher in the diabetic foot group than those without diabetic foot and the control subjects (p<0.05, p<0.001, and p<0.001 respectively). Patients with advanced diabetic foot lesions (Wagner grade 4-5) had higher soluble Fas and soluble Fas ligand levels (p<0.01 and p<0.01 respectively). Conclusions: We conclude that apoptotic pathway plays a role in the development of diabetic foot ulcers via Fas/ Fas ligand and osteoprotegerin. Since sFas and FasL were significantly higher in gangrenous foot lesions, sFas/FasL system may indicate the severity of inflammation and ongoing apoptosis.
- Subjects
APOPTOSIS; OSTEOPROTEGERIN; DIABETIC foot; ATHEROSCLEROSIS; ENDOCRINOLOGY
- Publication
Ortadogu Medical Journal / Ortadogu Tip Dergisi, 2013, Vol 5, Issue 4, p204
- ISSN
1309-3630
- Publication type
Article