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- Title
Sry-like high-mobility group box antibody-related paraneoplastic cerebellar degeneration in the background of underlying non-small cell lung cancer.
- Authors
Onder, Halil; Kurtulan, Olcay
- Abstract
Paraneoplastic neurological syndromes ( PNS) are defined as all non-metastatic neurological complications of cancer in which no other etiologies, such as vascular, infectious or metabolic, were determined. Recently, Sry-like high-mobility group box ( SOX1) antibody associated with PNS has been described, and is associated with Lambert-Eaton myasthenic syndrome, paraneoplastic cerebellar degeneration and paraneoplastic peripheral neuropathy invariably in the background of underlying small-cell lung cancer. A 75-year-old man was admitted to our neurology clinic at Hacettepe University Hospital, Sihhiye, Ankara, Turkey with complaints of imbalance and memory impairment that had started 2 months earlier and progressively increased. Neurological examination showed a state of delirium in the background of rapid progressive dementia and severely truncal ataxia. Cranial magnetic resonance imaging was unremarkable; however, in further investigations, thoracic tomography yielded bilateral hilar lymphadenopathy, and paraneoplastic antibody investigations resulted in positive SOX1 antibody. The following thoracic excisional lymph node biopsy investigations supported the diagnosis of non-small-cell lung cancer and paraneoplastic cerebellar degeneration associated with SOX1 antibody in the background of non-small-cell lung cancer. Adjuvant chemotherapy was started, but the patient deteriorated, which prevented proper plasmapheresis therapy. He died in the second month of admission as a result of severe sepsis leading to septic shock. Here, we show the second case diagnosed with PNS in association with non-small-cell lung cancer. We note the importance of SOX1 antibody as a marker for PNS, and suggest that investigations of this antibody be carried out in larger case studies.
- Subjects
PLASMAPHERESIS; CEREBELLUM degeneration; NON-small-cell lung carcinoma; LAMBERT-Eaton myasthenic syndrome; SRY gene; SOX transcription factors; DELIRIUM; THERAPEUTICS
- Publication
Clinical & Experimental Neuroimmunology, 2016, Vol 7, Issue 3, p281
- ISSN
1759-1961
- Publication type
Article
- DOI
10.1111/cen3.12311