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- Title
Autoimmune polyendocrine syndrome type 3 in a multiple sclerosis patient.
- Authors
Masuda, Saeko; Mori, Masahiro; Hamada, Shinsuke; Masuda, Hiroki; Uzawa, Akiyuki; Kuwabara, Satoshi
- Abstract
Autoimmune polyendocrine syndromes ( APS), a group of autoimmune-mediated multiple endocrine gland failure, type 3 is composed of autoimmune thyroid disease with endocrinopathy, including type 1 diabetes mellitus ( DM), other than adrenal insufficiency. Only a few cases of multiple sclerosis ( MS) with APS type 3 have been reported. We present the case of a 37-year-old Japanese man diagnosed with MS and Graves' disease at 22 years-of-age. Interferon-β-1b therapy, which he had previously discontinued for 10 years, was restarted for MS at 35 years-of-age. After the therapy, he complained of thirst and rapid bodyweight loss (15 kg/6 months), and developed type 1 DM. At onset of DM and before the restart of interferon-β-1b therapy, antiglutamic acid decarboxylase antibody findings had been positive. He was diagnosed as having APS type 3, associated Graves' disease and type 1 DM in addition to MS. Our case suggested that MS can be concomitant with APS type 3, and that interferon-β-1b therapy for a MS patient with a specific genetic background could induce onset of type 1 DM.
- Subjects
AUTOIMMUNE polyendocrinopathies; DIABETES risk factors; INTERFERON beta 1b; THERAPEUTICS
- Publication
Clinical & Experimental Neuroimmunology, 2015, Vol 6, Issue 3, p299
- ISSN
1759-1961
- Publication type
Article
- DOI
10.1111/cen3.12232