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- Title
Spinal anestezi uygulanan hastalarda propofol ve deksmedetomidinin hemodinamik parametreler ile serum IL-6 düzeylerine etkilerinin karşılaştırılması.
- Authors
Beyazoğlu, Orhan; Yalçın, Şaban; Aydoğan, Harun; Alp Karahan, Mahmut; Büyükfırat, Evren; Bilgiç, Tekin; Mordeni, Cengiz; Zeyrek, Fadile
- Abstract
Background: In this study, the effects of iv infusion of propofol and dexmedetomidine on hemodynamics and serum IL-6 levels in spinal anesthesia were evaluated. Methods: Ninety patients were enrolled to the study and divided to 3 equal groups. patients. Spinal anesthesia with 15 mg was applied to all groups. Group P (n=30) received 1 mg/kg/h propofol infusion, Group D (n=30) received 0.2 μg/kg/h dexmedetomidine infusion, Group S (n=30) received serum saline infusion during operation. Demographic parameters, motor block and operation times were recorded. Patients' intraoperative and postoperative hemodynamic parameters were monitorised; Ramsay sedation scale, postoperative side effects, first analgesic time and 24th hour total analgesic consumption were recorded. IL-6 levels in preoperative and postoperative 4th hour were evaluated. Results: Motor block time were longer in propofol group. In intraoperative period heart rate were significantly decreased in dexmedetomidine group and mean blood pressure and oxygen saturation significantly decreased in propofol group. In postoperative period heart rate and mean blood pressure were significantly decreased in dexmedetomidine group. Intraoperative and postoperative sedation scores were statistically higher in propofol group. There were no statistically significant differences between groups in serum IL-6 levels in preoperative and postoperative 4th hour. Conclusions: In conclusion, iv infusions of propofol and dexmedetomidine in spinal anesthesia have found to be similar effects on hemodynamics and prolonged block time. However, there was no superiority on control group and between each other in early postoperative period among IL-6 levels.
- Subjects
ANESTHESIA; COMPARATIVE studies; HEMODYNAMICS; IMIDAZOLES; INTERLEUKINS; SPINAL anesthesia; PROPOFOL
- Publication
Journal of Harran University Medical Faculty / Harran Üniversitesi Tıp Fakültesi Dergisi, 2011, Vol 8, Issue 3, p100
- ISSN
1304-9623
- Publication type
Article