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- Title
Hematological Indices for Differential Diagnosis of Beta Thalassemia Trait and Iron Deficiency Anemia.
- Authors
Vehapoglu, Aysel; Ozgurhan, Gamze; Demir, Ayşegul Dogan; Uzuner, Selcuk; Nursoy, Mustafa Atilla; Turkmen, Serdar; Kacan, Arzu
- Abstract
Background. The two most frequent types of microcytic anemia are beta thalassemia trait (β-TT) and iron deficiency anemia (IDA). We retrospectively evaluated the reliability of various indices for differential diagnosis of microcytosis and β-TT in the same patient groups. Methods. A total of 290 carefully selected children aged 1.1-16 years were evaluated. We calculated 12 discrimination indices in all patientswith hemoglobin (Hb) values of 8.7-11.4 g/dL. None of the subjects had a combined case of IDAand β-TT. All children with IDA received oral iron for 16weeks, and HbA2 screening was performed after iron therapy. The patient groupswere evaluated according to red blood cell (RBC) count; red blood distribution width index; the Mentzer, Shine and Lal, England and Fraser, Srivastava and Bevington, Green and King, Ricerca, Sirdah, and Ehsani indices; mean density of hemoglobin/liter of blood; and mean cell density of hemoglobin. Results. The Mentzer index was the most reliable index, as it had the highest sensitivity (98.7%), specificity (82.3%), and Youden's index (81%) for detecting β-TT; this was followed by the Ehsani index (94.8%, 73.5%, and 68.3%, resp.) and RBC count (94.8%, 70.5%, and 65.3%). Conclusion. The Mentzer index provided the highest reliabilities for differentiating β-TT from IDA.
- Subjects
DIFFERENTIAL diagnosis; IRON deficiency anemia diagnosis; THALASSEMIA diagnosis; RETROSPECTIVE studies; ERYTHROCYTES
- Publication
Anemia (20901267), 2014, p1
- ISSN
2090-1267
- Publication type
Article
- DOI
10.1155/2014/576738