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- Title
Human herpesvirus-6 pneumonitis in a patient with follicular lymphoma following immunochemotherapy with rituximab.
- Authors
Kuwahara-Ota, Saeko; Chinen, Yoshiaki; Mizuno, Yoshimi; Takimoto-Shimomura, Tomoko; Matsumura-Kimoto, Yayoi; Tanba, Kazuna; Tsukamoto, Taku; Mizutani, Shinsuke; Shimura, Yuji; Kobayashi, Tsutomu; Horiike, Shigeo; Kuroda, Junya
- Abstract
Primary infection with human herpesvirus-6 (HHV-6) commonly occurs at an early age in children, most often at 3 years of age, and is associated with childhood diseases, such as exanthema subitum, hepatitis, febrile convulsions, or encephalitis. However, the virus occasionally reactivates from its latent state in immunosuppressed adults, especially posttransplant, resulting in serious disseminated, sometimes life-threatening end-organ complications. Herein, we report a case of a 68-year-old man with relapsed follicular lymphoma who developed HHV-6 pneumonitis. Eighteen months after achieving second complete remission by salvage immunochemotherapy with rituximab, the patient was complicated by pneumonia, with chest computed tomography finding showing disseminated nodular shadows with ground-glass opacity in both lungs. While empiric antibiotic and antifungal therapies did not improve the pneumonia, polymerase chain reaction–based viral screening tests on his bronchoalveolar lavage fluid detected the presence of HHV-6 DNA, and ganciclovir treatment quickly resolved the pneumonia, indicating that he suffered from HHV-6 pneumonitis. He had no other HHV-6–related end-organ damage, such as encephalitis. This case suggests that, although extremely rare, HHV-6 reactivation should be considered as one of the candidate pathogens for pulmonary complications of uncertain etiology in patients who have been treated with intensive immunosuppressive chemotherapy, even without hematopoietic stem cell transplantation. Furthermore, polymerase chain reaction–based viral screening testing on bronchoalveolar lavage fluid is a powerful diagnostic tool for pneumonitis due to viral reactivation, including HHV-6 reactivation.
- Subjects
PNEUMONIA treatment; HUMAN herpesvirus-6; RITUXIMAB; IMMUNOCOMPROMISED patients; ANTIBIOTICS
- Publication
Infection & Drug Resistance, 2018, Vol 11, p701
- ISSN
1178-6973
- Publication type
Article
- DOI
10.2147/IDR.S163686