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- Title
Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures.
- Authors
Takashi Osamura; Yoshiko Takeuchi; Risako Onodera; Masahiro Kitamura; Yoshiteru Takahashi; Kohei Tahara; Hirofumi Takeuchi
- Abstract
We previously determined "Tableting properties" by using a multi-functional single-punch tablet press (GTP-1).We plotted "Compactability" on the x-axis against "Manufacturability" on the y-axis to allow visual evaluation of "Tableting properties". Here,we examined whether this evaluation method can be used in the formulation design of tablets prepared by wet granulation.We used the GTP-1 to measure "Tableting properties" with different amounts of binder, disintegrant, and lubricant, and compared the results with those of tableting on a commercial rotary tableting machine. Tableting failures (capping and binding in particular) occurred when samples that had been evaluated as having poor "Compactability" or "Manufacturability" on the GTP-1 were compressed on the rotary tableting machine. Thus, our evaluation method predicted tableting failure at the commercial scale. The method will prove useful for scaling up production.
- Subjects
DRUG tablets; DRUG development; DRUG granulation; MEDICAL care; PUBLIC health
- Publication
Asian Journal of Pharmaceutical Sciences, 2018, Vol 13, Issue 2, p113
- ISSN
1818-0876
- Publication type
Article
- DOI
10.1016/j.ajps.2017.08.002