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- Title
The promise and peril of chemical probes.
- Authors
Arrowsmith, Cheryl H; Audia, James E; Austin, Christopher; Baell, Jonathan; Bennett, Jonathan; Blagg, Julian; Bountra, Chas; Brennan, Paul E; Brown, Peter J; Bunnage, Mark E; Buser-Doepner, Carolyn; Campbell, Robert M; Carter, Adrian J; Cohen, Philip; Copeland, Robert A; Cravatt, Ben; Dahlin, Jayme L; Dhanak, Dashyant; Edwards, Aled M; Frye, Stephen V
- Abstract
The article presents the authors' argument on the need for a complementary approach for an open community resource about the quality of new chemical probes or to reduce the use of low-quality chemical probes. They provide definition of a chemical probe and highlight soma examples of high quality chemical probes and probes of lesser value. They also describe plans of creating a web-based resource comprising of the most appropriate chemical probe for a given protein target.
- Subjects
MOLECULAR probes; COMPUTER network resources; MOLECULAR biology techniques; PROTEINS; CHEMICAL biology
- Publication
Nature Chemical Biology, 2015, Vol 11, Issue 8, p536
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio.1867