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- Title
Enhancing In Vitro Bioactivity of Melt-Derived 45S5 Bioglass<sup>®</sup> by Comminution in a Stirred Media Mill.
- Authors
Romeis, Stefan; Hoppe, Alexander; Eisermann, Claudia; Schneider, Nadine; Boccaccini, Aldo R.; Schmidt, Jochen; Peukert, Wolfgang; Bose, S.
- Abstract
45S5 Bioglass® (45S5 BG) is a frequently applied Type A bioactive material, capable of forming an inherent bond to bone and soft tissue. Currently, applied melt-derived bioactive glass powders ( BG) exhibit particle sizes between a few to several hundred micrometers. Recent studies on nanometer-sized bioactive glasses (n BGs), produced by bottom-up methods like sol-gel processing or flame spray pyrolysis, have indicated their great potential for several biomedical applications. In this study, the feasibility of top-down processing starting from bulk 45S5 BG by wet comminution in a stirred media mill was investigated. The products were assessed by in vitro hydroxycarbonate apatite ( HCAp) formation in simulated body fluid, which is a marker for bioactive behavior. The study reveals the paramount influence of the used solvent for a successful top-down processing: In comparison with the as-received material bioactivity is lost for powders processed in water, preserved for comminution in ethanol and increased for powders processed using the alcohols n-butanol, n-pentanol, and n-hexanol. It was also found that only for the latter solvents, the chemical composition of the glass is maintained during comminution. Flake-like, slightly porous particles with specific surface areas of ~25-30 m2/g are obtained. Thus, the presented comminution approach offers a convenient technique to process 45S5 BG with enhanced bioactivity.
- Subjects
APATITE; CARBONATES; PYROLYSIS; SOLVENTS; PENTANOL
- Publication
Journal of the American Ceramic Society, 2014, Vol 97, Issue 1, p150
- ISSN
0002-7820
- Publication type
Article
- DOI
10.1111/jace.12615