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- Title
Interleukin (IL) -1 ß, IL-6 and tumor necrosis factor in patients with seasonal flu.
- Authors
Ramos, José M.; García-Navarro, Mar; Moreno, Victoria; González-de-la-Aleja, Pilar; Gimeno-Gascón, Adelina; Merino, Esperanza; Portilla, Joaquín
- Abstract
Introduction. The role of tumor necrosis factor (TNF), interleukin (IL)-1ß and IL-6 in the pathogenicity of seasonal flu is unknown. Methods. We analyzed the profiles of these cytokines in 77 flu patients and 17 controls with non-flu respiratory infection, using molecular biology techniques (real-time polymerase chain reaction). Results. Flu patients had lower monocyte counts (p=0.029) and a slightly lower median level of IL-6 (P=0.05) than the control group. Twenty-four flu patients (31.2%) had pneumonia; this group had higher C-reactive proteins (p=0.01) and monocyte levels (p=0.009). Pro-inflammatory cytokines levels did not rise in patients with pneumonia complicating seasonal influenza. Conclusion. IL-6 levels were lower in adults with influenza.
- Subjects
INTERLEUKIN-1; INTERLEUKIN-6; TUMOR necrosis factors; INFLUENZA; CYTOKINES
- Publication
Revista Española de Quimioterapia, 2018, Vol 31, Issue 6, p542
- ISSN
0214-3429
- Publication type
Article