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- Title
MYBL2 Is Targeted by miR-143-3p and Regulates Breast Cancer Cell Proliferation and Apoptosis.
- Authors
Jianli Chen; Xiaowen Chen
- Abstract
Breast cancer remains a public health issue on a global scale. The present study aimed to explore the functional role of MYB proto-oncogene like 2 (MYBL2) in breast cancer, as well as underlying mechanisms. The regulatory relationship between miR-143-3p and MYBL2 was analyzed, and the effects of dysregulation of miR-143-3p and MYBL2 on cell proliferation and apoptosis were investigated. The results showed that MYBL2 and miR-143-3p were inversely expressed in breast cancer tissues and cells: MYBL2 was highly expressed, whereas miR-143-3p was lowly expressed. MYBL2 was confirmed as a target gene of miR-143-3p. Suppression of MYBL2 inhibited proliferation and induced apoptosis of breast cancer cells, which was similar to the effects of overexpression of miR-143-3p. Our findings reveal that MYBL2 is targeted by miR-143-3p and regulates breast cancer cell proliferation and apoptosis.
- Subjects
CELL proliferation; APOPTOSIS; BREAST cancer; PROTO-oncogenes; GENETIC overexpression; CANCER cells; MICRORNA
- Publication
Oncology Research, 2018, Vol 26, Issue 6, p913
- ISSN
0965-0407
- Publication type
Article
- DOI
10.3727/096504017X15135941182107