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- Title
The effect of xamoterol in failing human myocardium.
- Authors
SCHWINGER, R. H. G.; BÖHM, M.; ERDMANN, E.
- Abstract
As the dual pharmacological action of partial β-adrenoceptor agonists should improve left ventricular function while also protecting the myocardium against excessive sympathetic stimulation they may be useful in the treatment of heart failure. Therefore, we studied the pharmacological effects of xamoterol (Corwin, ICl 118, 587), a compound with mixed agonist and antagonistic properties at cardiac β-adrenoceptors in electrically driven human papillary muscle strips from failing human hearts. Specimens were obtained from patients with different grades of myocardialfailure who underwent mitral valve replacement (NYHA II-III) or heart transplantation (NYHA IV). Xamoterol (0.0001-10.0 μmol 1) produced only negative inotropic effects, as measured by changes in isometric force of contraction in diseased human papillary muscle strips. However, isoprenaline (0.0001-10 μmol l) and ouabain (0.01-0.3 μmol 1) enhanced force of contraction in the same hearts. Prestimulation with noradrenaline (3 μmol l) augmented the negative inotropic effect of xamoterol. It is concluded that xamoterol exerts primarily β-adrenoceptor antagonistic activity in the failing human myocardium
- Publication
European Heart Journal, 1990, Vol 11, Issue 4, p323
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/oxfordjournals.eurheartj.a059705