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- Title
Copper-Mediated C6-Selective Dehydrogenative Heteroarylation of 2-Pyridones with 1,3-Azoles.
- Authors
Odani, Riko; Hirano, Koji; Satoh, Tetsuya; Miura, Masahiro
- Abstract
A copper-mediated C6-selective dehydrogenative heteroarylation of 2-pyridones with 1,3-azoles has been developed. The reaction proceeded smoothly by twofold CH cleavage even in the absence of noble-metal catalysts. The observed site selectivity was directed by a pyridyl substituent on the nitrogen atom of the pyridone ring. This directing group was readily removed after the coupling event, thus leading to 2-pyridone derivatives with a free NH group. Moreover, in some cases, catalytic turnover of the Cu salt was also possible with the ideal terminal oxidant: molecular oxygen in air.
- Subjects
ARYLATION; SCISSION (Chemistry); COPPER oxide; PYRIDONE; METAL catalysts; PYRIDYL compounds
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 40, p10784
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201406228