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- Title
Vanadium-Catalyzed Solvent-Free Synthesis of Quaternary α-Trifluoromethyl Nitriles by Electrophilic Trifluoromethylation.
- Authors
Früh, Natalja; Togni, Antonio
- Abstract
The direct electrophilic trifluoromethylation of silyl ketene imines (SKIs) with hypervalent iodine reagents leads to the formation of quaternary α-trifluoromethyl nitriles in good yields. This new reaction has been carried out with a variety of substituted SKIs under solvent-free conditions using a vanadium(IV) catalyst (5 mol %). The corresponding products may be transformed into useful organofluorine building blocks.
- Subjects
NITRILES; CHROMIUM-cobalt-nickel-molybdenum alloys; QUATERNARY forms; ORGANIC chemistry; IMINE derivatives; VANADIUM
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 40, p10813
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201406181