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- Title
Host-mediated RNA editing in viruses.
- Authors
Zhu, Tongtong; Niu, Guangyi; Zhang, Yuansheng; Chen, Ming; Li, Chuan-Yun; Hao, Lili; Zhang, Zhang
- Abstract
Viruses rely on hosts for life and reproduction, cause a variety of symptoms from common cold to AIDS to COVID-19 and provoke public health threats claiming millions of lives around the globe. RNA editing, as a crucial co-/post-transcriptional modification inducing nucleotide alterations on both endogenous and exogenous RNA sequences, exerts significant influences on virus replication, protein synthesis, infectivity and toxicity. Hitherto, a number of host-mediated RNA editing sites have been identified in diverse viruses, yet lacking a full picture of RNA editing-associated mechanisms and effects in different classes of viruses. Here we synthesize the current knowledge of host-mediated RNA editing in a variety of viruses by considering two enzyme families, viz., ADARs and APOBECs, thereby presenting a landscape of diverse editing mechanisms and effects between viruses and hosts. In the ongoing pandemic, our study promises to provide potentially valuable insights for better understanding host-mediated RNA editing on ever-reported and newly-emerging viruses.
- Subjects
RNA editing; COVID-19 pandemic; PLANT viruses; RNA viruses; COMMON cold
- Publication
Biology Direct, 2023, Vol 18, Issue 1, p1
- ISSN
1745-6150
- Publication type
Article
- DOI
10.1186/s13062-023-00366-w