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- Title
Tn, a carcinoma-associated antigen, reacts with anti-Tn of normal human sera.
- Authors
Springer, Georg F.; Taylor, Clive R.; Howard, Donald R.; Tegtmeyer, Herta; Desai, Parimal R.; Murthy, Satya M.; Felder, Barbara; Scanlon, Edward F.; Springer, G F; Taylor, C R; Howard, D R; Tegtmeyer, H; Desai, P R; Murthy, S M; Felder, B; Scanlon, E F
- Abstract
Tn antigen is the immediate precursor of the carcinoma (CA)-associated T antigen; both are masked in non-CA tissues. Tn antigen was detected by absorption of human anti-Tn antibody in 46 of 50 primary breast CAs and in all 6 metastases originating from Tn-positive primary CAs. Thirteen of 25 (52%) anaplastic CAs, but only 2 of 15 (13%) well differentiated CAs had more Tn than T; 1 anaplastic CA had neither antigen. Eighteen of 20 benign breast lesions had no Tn; the 2 positive lesions were premalignant. All 19 breast CAs, studied immunohistochemically, reacted strongly with human polyclonal anti-Tn; benign or normal glandular tissues had minimal or no reactivity. Among live cancer cell lines, the most malignant sublines had more Tn than T on their cell surfaces. Preliminary studies with rodent monoclonal anti-Tn and anti-T antibodies gave immunohistochemical reactivity patterns similar to those of the polyclonal antibodies, but the former were less sensitive in absorption tests. Tn is a CA marker that promises to be useful in tumor detection.
- Publication
Cancer (0008543X), 1985, Vol 55, Issue 3, p561
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19850201)55:3<561::AID-CNCR2820550315>3.0.CO;2-1