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- Title
Nonseminomatous germ cell cancer of the testis. Reducing treatment-related morbidity in patients with disseminated disease.
- Authors
Paschal, Barton R.; Muss, Hyman B.; Richards, Frederick; Cooper, M. Robert; White, Douglas R.; Jackson, Don V.; Stuart, John J.; Spurr, Charles L.; Paschal, B R; Muss, H B; Richards, F 2nd; Cooper, M R; White, D R; Jackson, D V; Stuart, J J; Spurr, C L
- Abstract
Fourteen previously untreated patients with metastatic nonseminomatous germ cell cancer of the testis (NSGC) were treated with a modified VAB-4 regimen which was designed to reduce treatment-related morbidity. Nine of 10 patients with minimal disease and the only patient with advanced pulmonary disease achieved a complete response (CR) with chemotherapy alone. Two of three partial responders with advanced abdominal disease were converted to CR status with radiotherapy and/or surgery. None of the 12 CRs have relapsed (median duration of follow-up, 28+ months). We observed no granulocytopenic fever or permanent renal insufficiency. These results indicate that NSGC patients with a low tumor burden can be spared substantial toxicity without adversely affecting complete response rates.
- Publication
Cancer (0008543X), 1982, Vol 50, Issue 9, p1742
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19821101)50:9<1742::AID-CNCR2820500916>3.0.CO;2-U