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- Title
CD158k/KIR3DL2 Is a New Phenotypic Marker of Sezary Cells: Relevance for the Diagnosis and Follow-Up of Sezary Syndrome.
- Authors
Poszepczynska-Guigné, Ewa; Schiavon, Valérie; D'incan, Michel; Echchakir, Hamid; Musette, Philippe; Ortonne, Nicolas; Boumsell, Laurence; Moretta, Alessandro; Bensussan, Armand; Bagot, Marfine
- Abstract
CD158k molecules belong to the family of killer cell immunoglobulin-like receptors (KIR) that are expressed on a minor population of circulating NK and CD8+ T lymphocytes. Here, we report a strong positive correlation between the percentage of CD158k+ blood lymphocytes analyzed by flow cytometry and the percentage of atypical circulating cells (Sezary cells) determined by cytomorphology in a large group of patients with Sezary syndrome. Moreover, we show that circulating CD4+CD158k+ lymphocytes correspond to the malignant clonal cell population. Our findings suggest that the CD158k marker could be a useful tool for the evaluation of the circulating tumoral burden and the follow-up of patients with Sezary syndrome.
- Subjects
TUMOR markers; BIOMARKERS; CELL proliferation; IMMUNOGLOBULINS; SYNDROMES; LYMPHOCYTES
- Publication
Journal of Investigative Dermatology, 2004, Vol 122, Issue 3, p820
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/j.0022-202X.2004.22326.x