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- Title
Regulation of Cutaneous Allergic Reaction by Odorant Inhalation.
- Authors
Hosoi, Junichi; Tsuchiya, Toru
- Abstract
Summary Olfactory stimuli modulate emotional conditions and the whole body immune system. Effects of odorant inhalation on cutaneous immune reaction were examined. Contact hypersensitivity to 2,4,6-trinitrochlorobenzene was elicited in C57BL/6 mice. The reaction was suppressed at both the induction and elicitation phases by exposure to an odorant, citralva. Topical application of citralva or lyral/lilial did not affect the reaction. The suppressive effect of citralva was more potent than that of another odorant, lyral/lilial. Citralva decreased the number of epidermal Langerhans cells, whereas lyral/lilial had a weak effect. Citralva but not lyral/lilial induced plasma corticosterone. Glucocorticoid receptor antagonist abrogated the suppressive effect of citralva on contact hypersensitivity. Serum interleukin-12 was downregulated by exposure to citralva or lyral/lilial. These data demonstrate that olfactory stimuli regulate the cutaneous immune system.
- Subjects
ODORS; ALLERGIES
- Publication
Journal of Investigative Dermatology, 2000, Vol 114, Issue 3, p541
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1046/j.1523-1747.2000.00896.x