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- Title
A novel B allele with c.736T>C, c.738C>A, and c.930A>G variations identified in a Chinese individual with Bw phenotype.
- Authors
Zhang, Bing; Hong, Xiaozhen; Xu, Xianguo; Zhu, Faming
- Abstract
By direct sequence analysis and compared to the I ABO*A1.01 i allele, 17 heterozygous nucleotide sites in the coding region of the I ABO i gene were found which included c.106G/T, c.188G/A, c.189C/T, c.220C/T, c.261G/delG, 297G/G, c.526C/G, c.646T/A, c.657C/T, c.681G/A, c.703G/A, c.736T/C, c738C/A, c.771C/T, c.796C/A, c.803G/C and c.829G/A. Among them, c.297G, c.526G, c.657T, c.703A, c.796A, c.803C were associated with the I B i allele, and c.297G and the others were associated with the I O i allele. Full coding nucleotide sequence of the I ABO i gene was detected using a polymerase chain reaction sequence-based typing.[3] The haploid sequence of the exons 2-7 of the I ABO i gene was analyzed using an allele-specific primer sequencing technology according to our previous report.[4] RESULTS AND DISCUSSION The proband was a blood donor in the Blood Center of Zhejiang Province, China. Keywords: blood group genomics; immunohematology EN blood group genomics immunohematology E25 E26 2 04/13/23 20230401 NES 230401 Forty-four blood group systems have been identified up to now.[1] However, the ABO blood group system is the most important in transfusion and transplantation.[2] In addition to normal A, B, O, and AB phenotypes in the ABO blood group system, there are also existed some ABO subgroups with antigen weaken expression.
- Subjects
ABO blood group system; PHENOTYPES; ALLELES
- Publication
Transfusion, 2023, Vol 63, Issue 4, pE25
- ISSN
0041-1132
- Publication type
Article
- DOI
10.1111/trf.17299