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- Title
Mortality in cold agglutinin disease shows seasonal pattern.
- Authors
Hansen, Dennis Lund; Möller, Sören; Berentsen, Sigbjørn; Frederiksen, Henrik
- Abstract
We have with great interest read the recent publication by Röth et al. illustrating that patients with cold agglutinin disease (CAD) have persistent biochemical hemolysis all year round.1 The study supports that anemia, hemolysis, and directly related symptoms like fatigue persist through seasons. In order to address this we used our cohort including all patients diagnosed in Denmark with CAD or autoimmune hemolytic anemia (AIHA), and for each patient in the two categories up to 50 age-sex-matched comparators from the general population.3 Denmark has nationwide health registers deriving from a universal, tax-funded health system providing a complete inclusion and minimal loss to follow up.4 We included patients diagnosed from 1980 to 2016 for AIHA and 1994 to 2016 for CAD. The two groups of patients with CAD and AIHA differed in mean age at diagnosis and sex distribution, but patient groups and corresponding comparator groups were similar by study design, Table S1.
- Publication
Transfusion, 2022, Vol 62, Issue 7, p1460
- ISSN
0041-1132
- Publication type
Article
- DOI
10.1111/trf.16894