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- Title
Differential prognostic impact of CD8<sup>+</sup> T cells based on human leucocyte antigen I and PD-L1 expression in microsatellite-unstable gastric cancer.
- Authors
Kwak, Yoonjin; Koh, Jiwon; Park, Yujun; Hong, Yun Ji; Park, Kyoung Un; Kim, Hyung-Ho; Park, Do Joong; Ahn, Sang-Hoon; Kim, Woo Ho; Lee, Hye Seung
- Abstract
<bold>Background: </bold>The aim of the study was to determine the human leucocyte antigen class-I (HLA-I), programmed death-ligand 1 (PD-L1) expression and tumour-infiltrating lymphocytes (TILs) of microsatellite instability-high gastric cancer.<bold>Methods: </bold>The HLA-I expression type was determined by immunohistochemistry of HLA-A, HLA-B, HLA-C and β2-microglobulin in the centre of the tumour (CT) and in the invasive margin (IM) of samples from 293 patients (total loss vs. preserved type). PD-L1 expression and TIL density was examined immunohistochemically. HLA-I genotyping was also performed.<bold>Results: </bold>The expression loss of the HLA-I molecules was significantly associated with low TIL density. According to survival analyses, the HLA-I expression type and PD-L1 positivity were not independent prognostic factors. The TIL density had no prognostic implication when survival analysis was performed for the whole patient group; however, high CD8+ TIL infiltration was significantly associated with good prognosis in only HLA-I-preserved-type/PD-L1-positive group (p = 0.034). The homozygosity of the HLA-I allele was more frequently observed in the total loss type group.<bold>Conclusions: </bold>We confirmed differential prognostic implication of CD8+ TILs according to the HLA-I and PD-L1 expression. Determination of the HLA-I expression could be helpful to select patients who would benefit from anti-PD-1/PD-L1 therapy.
- Subjects
LYMPHOCYTE metabolism; STOMACH tumors; RESEARCH; RESEARCH methodology; PROGNOSIS; CELL physiology; EVALUATION research; MEDICAL cooperation; LYMPHOCYTES; COMPARATIVE studies; GENOTYPES; KAPLAN-Meier estimator; T cells; DEGENERATION (Pathology); ANTIGENS; HISTOCOMPATIBILITY antigens
- Publication
British Journal of Cancer, 2020, Vol 122, Issue 9, p1399
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/s41416-020-0793-y