We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma.
- Authors
Molven, Anders; Puig-Butille, Joan Anton; Andresen, Per A; van Doorn, Remco; Taylor, John C; Hočevar, Marko; Lee, Jeffrey E; Fang, Shenying; Pharoah, Paul D P; Radford-Smith, Graham L; Schadendorf, Dirk; Kypreou, Katerina P; Stratigos, Alexander J; Bishop, D Timothy; Barrett, Jennifer H; Bishop, Julia A Newton; Mann, Graham J; Montgomery, Grant W; Craig, Jamie E; Martin, Nicholas G
- Abstract
Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10−8), as did 2 previously reported but unreplicated loci and all 13 established loci. Newly associated SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes in the associated regions, including one involved in telomere biology.
- Subjects
MELANOMA; HUMAN genome; META-analysis; SINGLE nucleotide polymorphisms; TELOMERES; GENETICS
- Publication
Nature Genetics, 2015, Vol 47, Issue 9, p987
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.3373