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- Title
Variant in PNPLA3 is associated with alcoholic liver disease.
- Authors
Chao Tian; Stokowski, Renee P.; Kershenobich, David; Ballinger, Dennis G.; Hinds, David A.
- Abstract
Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the contributions of these variants to liver disease in Mestizo subjects with a history of alcohol dependence. We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P=1.7 × 10−10; ancestry-adjusted OR=1.79, P=1.9 × 10−5).
- Subjects
LIVER diseases; FATTY liver; ENZYMES; CIRRHOSIS of the liver; COMPLICATIONS of alcoholism; MESTIZOS
- Publication
Nature Genetics, 2010, Vol 42, Issue 1, p21
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.488