We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The relationship between serum IGF-1, handgrip strength, physical performance and falls in elderly men and women.
- Authors
van Nieuwpoort, I. C.; Vlot, M. C.; Schaap, L. A.; Lips, P.; Drent, M. L.
- Abstract
Objective: Human aging is accompanied by a decrease in growth hormone secretion and serum insulin-like growth factor (IGF)-1 levels. Also, loss of muscle mass and strength and impairment of physical performance, ending in a state of frailty, are seen in elderly. We aimed to investigate whether handgrip strength, physical performance and recurrent falls are related to serum IGF-1 levels in community-dwelling elderly. Design: Observational cohort study (cross-sectional and prospective). Methods: We studied the association between IGF-1 and handgrip strength, physical performance and falls in participants of the Longitudinal Aging Study Amsterdam. A total of 1292 participants were included (633 men, 659 women). Serum IGF-1 levels were divided into quartiles (IGF-1-Q1 to IGF-1-Q4). Data on falls were collected prospectively for a period of 3 years. All analyses were stratified for age and physical activity and adjusted for relevant confounders. Results: Men with a low physical activity score in IGF-1-Q1 and IGF-1-Q2 of the younger age group had a lower handgrip strength compared to IGF-1-Q4. In younger more active males in IGF-1-Q2 physical performance was worse. Recurrent fallers were less prevalent in older, low active males with low IGF-1 levels. In females, recurrent fallers were more prevalent in older, more active females in IGF-1-Q2. IGF-1 quartile may predict changes in handgrip strength and physical performance in men and women. Conclusions: Our results indicate that lower IGF-1 levels are associated with lower handgrip strength and worse physical performance, but less recurrent fallers especially in men. Associations were often more robust in IGF-1-Q2. Future studies on this topic are desirable.
- Subjects
PHYSICAL fitness for older people; SOMATOMEDIN C; ACCIDENTAL falls in old age
- Publication
European Journal of Endocrinology, 2018, Vol 179, Issue 2, p73
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1530/EJE-18-0076