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- Title
Helminthostachys zeylanica alleviates hepatic steatosis and insulin resistance in diet-induced obese mice.
- Authors
Chang, Ting-Chen; Chiang, Hao; Lai, Yu-Heng; Huang, Yu-Ling; Huang, Hsiu-Chen; Liang, Yu-Chih; Liu, Hui-Kang; Huang, Cheng
- Abstract
Background: Obesity and its associated health conditions, type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD), are worldwide health problems. It has been shown that insulin resistance is associated with increased hepatic lipid and causes hepatic steatosis through a myriad of mechanisms, including inflammatory signaling. Methods: Helminthostachys zeylanica (HZ) is used widely as a common herbal medicine to relieve fever symptoms and inflammatory diseases in Asia. In the present study, we evaluated whether HZ has therapeutic effects on obesity, NAFLD and insulin resistance. The protective effects of HZ extract were examined using free fatty acid-induced steatosis in human HuS-E/2 cells and a high-fat diet-induced NAFLD in mice. Results: The major components of the HZ extract are ugonins J and K, confirmed by HPLC. Incubation of human hepatocytes, HuS-E/2 cells, with palmitate markedly increased lipid accumulation and treatment with the HZ extract significantly decreased lipid deposition and facilitated AMPK and ACC activation. After 12 weeks of a high-fat diet with HZ extract treatment, the HFD mice were protected from hyperlipidemia and hyperglycemia. HZ extract prevented body weight gain, adipose tissue expansion and adipocyte hypertrophy in the HFD mice. In addition, fat accumulation was reduced in mice livers. Moreover, the insulin sensitivity-associated index, which evaluates insulin function, was also significantly restored. Conclusions: These results suggest that HZ has a promising pharmacological effect on high-fat diet-induced obesity, hepatic steatosis and insulin resistance, which may have the potential for clinical application.
- Subjects
HYPERGLYCEMIA prevention; PREVENTION of obesity; WEIGHT gain prevention; FATTY liver prevention; ADIPOSE tissues; ANIMAL experimentation; BLOOD sugar; ENZYMES; FAT; FAT cells; FATTY acids; FATTY liver; FEVER; FAT content of food; HERBAL medicine; HIGH performance liquid chromatography; HYPERLIPIDEMIA; INFLAMMATORY bowel diseases; INSULIN resistance; LIPIDS; LIVER; LIVER cells; MICE; MOLECULAR structure; OBESITY; PROTEIN kinases; PLANT extracts
- Publication
BMC Complementary & Alternative Medicine, 2019, Vol 19, Issue 1, p1
- ISSN
1472-6882
- Publication type
Article
- DOI
10.1186/s12906-019-2782-3