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- Title
MHC class I molecules are incorporated into human herpesvirus-6 viral particles and released into the extracellular environment.
- Authors
Ota, Megumi; Serada, Satoshi; Naka, Tetsuji; Mori, Yasuko
- Abstract
ABSTRACT Human herpesvirus-6 (HHV-6), which belongs to the betaherpesvirus subfamily, mainly replicates in T lymphocytes. Here, we show that MHC class I molecules are incorporated into HHV-6 viral particles and released into the extracellular environment. In addition, HHV-6A/B-infected T cells showed reduced surface and intracellular expression of MHC class I molecules. The cellular machinery responsible for molecular transport appears to be modified upon HHV-6 infection, causing MHC class I molecules to be transported to virion assembly sites.
- Subjects
HUMAN herpesvirus-6; EXTRACELLULAR matrix; HERPESVIRUS diseases; T cells; INTRACELLULAR membranes; VIROLOGY
- Publication
Microbiology & Immunology, 2014, Vol 58, Issue 2, p119
- ISSN
0385-5600
- Publication type
Article
- DOI
10.1111/1348-0421.12121