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- Title
Genetical Genomics: Spotlight on QTL Hotspots.
- Authors
Breitling, Rainer; Yang Li; Tesson, Bruno M.; Jingyuan Fu; Chunlei Wu; Wiltshire, Tim; Gerrits, Alice; Bystrykh, Leonid V.; de Haan, Gerald; Su, Andrew I.; Ritsert C. Jansen
- Abstract
In this article, the authors discuss the genetical genomics which aims at the identification of quantitative trait loci (QTL) for gene expression. The authors consider the genetic polymorphisms as expression-QTL hotspots which lead to consistent biological effects. They explained the result of the permutation test used for QTL detection, which shows a false discovery rate of 64 percent.
- Subjects
GENOMICS; GENETIC polymorphisms; GENE expression; LOCUS (Genetics); MOLECULAR genetics; PERMUTATIONS
- Publication
PLoS Genetics, 2008, Vol 4, Issue 10, p1
- ISSN
1553-7390
- Publication type
Opinion
- DOI
10.1371/journal.pgen.1000232