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- Title
An INKlination for epigenetic control of senescence.
- Authors
Peters, Gordon
- Abstract
The article discusses a study published in the current issue concerning the links between the Ink4a-Arf locus, cellular senescence and stem cell maintenance. The study found that short hairpin RNA-mediated knockdown of the H3K36 demethylase 1b in primary embryonic fibroblasts results in premature senescence.
- Subjects
CELLULAR aging; AGING; STEM cells; FIBROBLASTS; EMBRYOLOGY
- Publication
Nature Structural & Molecular Biology, 2008, Vol 15, Issue 11, p1133
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb1108-1133