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- Title
Fertility management in the PCOS population: results of a web-based survey at IVF-worldwide.com.
- Authors
Brezina, Paul; Mensah, Virginia; Balen, Adam; Leong, Milton; Weissman, Ariel; Zhao, Yulian; Shoham, Zeev
- Abstract
Purpose: To identify the leading treatment strategies for infertile women with PCOS on an international scale. Methods: A retrospective evaluation using the results of a web-based survey, (IVF-Worldwide (), posted from 1 to 30 September 2010 was performed. Binomial confidence intervals for proportions were calculated by the modified Wald method with significance defined as P < 0.05 using a DataStar software package (DataStar, Waltham, MA, USA). Incomplete surveys were excluded from the analysis. Results: The results from 262 centers in 68 nations were obtained. Clomiphene citrate was the clear first choice, 68 %, for PCOS treatment in the respondent group. Eighty-eight percent of respondents utilized ultrasound follicular monitoring when conducting ovulation induction with oral medications. A significant ( p < 0.05) proportion of respondents (66 %) did use some BMI cutoff beyond which IVF treatment was not offered. The preferred IVF protocols for PCOS patients were gonadotropin releasing hormone (GnRH) antagonist, 46 %, and GnRH agonist, 51 %. There was heterogeneity of responses observed regarding the management of a patient at very high risk of OHSS. Conclusions: While some advances, such as the use of GnRH antagonist regimen in IVF cycles, were relatively underutilized, the survey gives an unfiltered snapshot at the practice patterns of a large number of clinics. Results from this survey may be used by researchers and professional organizations to improve the clinical care of PCOS women suffering with infertility.
- Subjects
FEMALE infertility; POLYCYSTIC ovary syndrome; FERTILIZATION in vitro; CONFIDENCE intervals; BODY mass index; LUTEINIZING hormone releasing hormone; CLOMIPHENE; THERAPEUTICS
- Publication
Journal of Assisted Reproduction & Genetics, 2013, Vol 30, Issue 9, p1169
- ISSN
1058-0468
- Publication type
Article
- DOI
10.1007/s10815-013-0069-z