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- Title
Nanolobatone A, An Unprecedented Diterpenoid and Related New Casbanoids from the Hainan Soft Coral Sinularia nanolobata.
- Authors
Liu, Jiao; Li, Song‐Wei; Zhao, Qing‐Min; Zhang, Zai‐Yong; Yao, Li‐Gong; Gu, Yu‐Cheng; Lan, Le‐Fu; Guo, Yue‐Wei
- Abstract
Nanolobatone A, featuring an unprecedented tricyclo[10.3.0.01,2]pentadecane carbon skeleton, along with four new polyoxygenated and four unusual endoperoxide‐bridged casbane‐type diterpenoids were isolated from the Hainan soft coral Sinularia nanolobata. The structures of the new compounds were established by extensive spectroscopic analysis, X‐ray diffraction analysis, and time‐dependent density functional theory/electronic circular dichroism calculations. A plausible biosynthetic pathway of new isolates was proposed. Bioassays revealed that nanolobatone A showed weak antibacterial activity against the Gram‐positive bacteria Streptococcus pyogenes.
- Subjects
HAINAN Sheng (China); ALCYONACEA; CIRCULAR dichroism; TIME-dependent density functional theory; STREPTOCOCCUS pyogenes
- Publication
Chemistry - A European Journal, 2023, Vol 29, Issue 26, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202300055