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- Title
Inhibition of mRNA synthesis in the hippocampus impairs consolidation and reconsolidation of spatial memory.
- Authors
Da Silva, Weber C.; Bonini, Juliana S.; Bevilaqua, Lia R.M.; Medina, Jorge H.; Izquierdo, Iván; Cammarota, Martín
- Abstract
Using two different mRNA synthesis inhibitors, we show that blockade of hippocampal gene expression during restricted posttraining or postretrieval time windows hinders retention of long-term spatial memory for the Morris water maze task, without affecting short-term memory, nonspatial learning, or the functionality of the hippocampus. Our results indicate that spatial memory consolidation induces the activation of the hippocampal transcriptional machinery and suggest the existence of a gene expression-dependent reconsolidation process that operates in the dorsal hippocampus at the moment of retrieval to stabilize the reactivated mnemonic trace. © 2007 Wiley-Liss, Inc.
- Publication
Hippocampus, 2008, Vol 18, Issue 1, p29
- ISSN
1050-9631
- Publication type
Article
- DOI
10.1002/hipo.20362