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- Title
Well-differentiated and dedifferentiated liposarcomas.
- Authors
Coindre, Jean-Michel; Pédeutour, Florence; Aurias, Alain; Pédeutour, Florence
- Abstract
Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality characterized by a simple genomic profile with a 12q14-15 amplification involving MDM2 gene. These tumors are the most frequent LPS. This paper reviews the molecular pathology, general clinical and imaging features, histopathology, new diagnostic tools, and prognosis of ALT-WDLPS and DDLPS.
- Subjects
LIPOSARCOMA; MOLECULAR biology; TUMORS; PATHOLOGICAL physiology; GENES
- Publication
Virchows Archiv: European Journal of Pathology, 2010, Vol 456, Issue 2, p167
- ISSN
0945-6317
- Publication type
journal article
- DOI
10.1007/s00428-009-0815-x