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- Title
Remittance at a single wavelength of 390 nmto quantify epidermal melanin concentration.
- Authors
Wim Verkruysse; Lars O. Svaasand; Walfre Franco; J. Stuart Nelson
- Abstract
Objective quantification of epidermal melanin concentration (EMC) should be useful in laser dermatology to determine the individual maximum safe radiant exposure (IMSRE). We propose a single-wavelength remittance measurement at 390 nmas an alternative optical method to determine EMC and IMSRE. Remittance spectra (360 to 740 nm), melanin index (MI) measurements and the transient radiometric temperature increase, T(t), upon skin irradiation with an Alexandrite laser (755 nm, 3-mspulse duration, 6 Jcm2) were measured on 749 skin spots (arm and calf) on 23 volunteers (skin phototypes I to IV). Due to the shallow penetration depth and independence of blood oxygen saturation (isosbestic point), remittance at 390 nmappears to provide better estimates for EMC and IMSRE than MI.
- Subjects
LASERS; SKIN diseases; MELANINS; DERMATOLOGY
- Publication
Journal of Biomedical Optics, 2009, Vol 14, Issue 1, p14005
- ISSN
1083-3668
- Publication type
Article
- DOI
10.1117/1.3065542